During the 2009-10 H1N1 or “swine flu” pandemic, the same virus that caused mild coughing and sneezing in some patients proved fatal for others. It highlighted a medical mystery: why are some people more fit to handle the flu than others?
British and American researchers think they have a clue. Reporting on Sunday in the journal Nature, researchers say they’ve found a gene that influences our susceptibility to flu illness. The gene, called IFITM3, is the “crucial first line of defense” against the flu, researcher Paul Kellam of Britain’s Sanger Institute told Reuters.
The IFITM3 protein prevents flu virusES from replicating in cells, sending them straight to waste disposal instead. So, if you have a high amount of IFITM3, you’re in luck, since it weakens the spread of the virus; a low amount can lead to more rapid viral replication, causing severe flu symptoms, according to Kellam.
Scientists first found IFITM3 in gene studies that showed that IFITM3 played a role in resistance to flu and other viruses like dengue fever and West Nile virus. In subsequent experiments in mice, they showed that when mice were bred to lack the IFITM3 gene and then infected with influenza, the animals developed more severe respiratory and lung infection from flu, including pneumonia, compared with mice that had the gene.
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